ISO/IEC 23092-3:2025

This document specifies information metadata, metrics metadata, clinical data linkage metadata, auxiliary fields, SAM interoperability, protection metadata and programming interfaces of genomic information. It defines: — metadata storage and interpretation for the different encapsulation levels as specified in ISO/IEC 23092-1 (in Clause 6); — metrics metadata containing sequencing data metrics at the dataset and access unit levels as specified in ISO/IEC 23092-1 (in Clause 7); — clinical data linkage metadata stored at the dataset group, dataset and annotation table levels as specified in ISO/IEC 23092-1 (in Clause 8); — protection elements providing confidentiality, integrity and privacy rules at the different encapsulation levels as specified in ISO/IEC 23092-1 (in Clause 9); — how to associate auxiliary fields to encoded reads (in Clause 10); — interfaces to access genomic information coded in compliance with ISO/IEC 23092-1 and ISO/IEC 23092-2 (in Clause 12); — mechanisms for backward compatibility with existing SAM content, and exportation to this format (in Annex E).